SUMO unloads the Kap114 cab

SUMO unloads the Kap114 cab.

Nucleocytoplasmic transport is an essential mechanism in all eukaryotic cells, for which the basic mechanisms seemed well understood. Transport receptors of the importin b/karyopherin family recognize, translocate and discharge cargo. Key to directed transport is the GTPase Ran, which determines compartment-specific interactions between receptors and their cargo. In this issue of The EMBO Journ...

Sumoylation regulates Kap114-mediated nuclear transport.

The nuclear import receptor Kap114 carries transcription factors and other cargos across nuclear pores into the nucleus. Here we show that yeast Kap114 is modified by SUMO (small ubiquitin-related modifier) and that sumoylation is required for Kap114-mediated nuclear import. Among the four known SUMO-specific E3 ligases in yeast, Mms21 is the preferred E3 enzyme responsible for the covalent att...

THE Cab CURVE

We characterize the defining equation of a plane algebraic curve with exactly one rational place Q at infinity, then give a basis of L(mQ) with pairwise distinct pole orders at Q. The defining equation can be regarded as a generalization of the Weierstrass form of a hyperelliptic curve. In this informal note I give an English proof of the results of the Cab curve found by Miura [4, 5, 6]. Throu...

An Arabidopsis cab gene homologous to Cab-8 of tomato.

Prone positioning unloads the right ventricle in severe ARDS.

BACKGROUND Despite airway pressure limitation, acute cor pulmonale persists in a minority of ARDS patients. Insufficient airway pressure limitation, hypercapnia, or both may be responsible. Because prone positioning (PP) has been shown to be a safe way to reduce airway pressure and to improve alveolar ventilation, we decided to assess its effect on right ventricular (RV) pressure overload in AR...